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At first, we will know what is excipients?
Why excipients used in dosage form formulation?
Excipients is a chemical substance that is pharmacologically inactive, chemically inert and physically stable.
What is the role of excipients?
Why excipients used in dosage form formulation?
Excipients is a chemical substance that is pharmacologically inactive, chemically inert and physically stable.
What is the role of excipients?
- Excipients make up the bulk of the total dosage form
- It makes the product taste and looks better
EXCIPIENTS (ADDITIVES) USED IN DOSAGE FORM FORMULATION
There are several excipients used in dosage form formulation following-
1. Diluents: Diluents are filters used to makeup required bulk of dosage form when dosage form itself is inadequate to produce the bulk.
example: lactose, sucrose, mannitol, dextrose etc.
2. Binders: This material are added cohesiveness to powders, thus provide necessary bonding to form granules
examples: Acacia, methylcellulose, starch etc.
3. Disintegrants: These are added to facilitate the breaking of the dosage form(tablets, capsules) when it comes to contact with GI Fluid.
examples: avicel, sodium alginate etc.
4. Lubricants: Lubricants are added to reduce the friction during tablets ejection from the die cavity.
example: calcium stearate, magnesium stearate etc.
5. Glidants: Glidants are intended to increase the flow of granules by reducing the friction between the particles.
examples: corn-starch, talc etc.
6. Colours: Colours are added to cover the colour of drugs and gives better colour.
examples: carotene, chlorophyll etc.
7. Sweeteners: Sweeteners are added to tablet formulation to improve the taste of dosage form.
example: aspartame, dextrose etc.
8. Flavours: Flavours are added to make them tasty enough.
example:- vanilla, anise cherry etc.
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